Mariska de Munnik

Sep 17, 2024 | nature.com | Mariska de Munnik |Pauline A. Lang |Patrick Rabe |Jurgen Brem

AbstractThe essential l,d-transpeptidase of Mycobacterium tuberculosis (LdtMt2) catalyses the formation of 3\(\to\)3 cross-links in cell wall peptidoglycan and is a target for development of antituberculosis therapeutics. Efforts to inhibit LdtMt2 have been hampered by lack of knowledge of how it binds its substrate.

Oct 2, 2023 | pubs.rsc.org | Mariska de Munnik |Jasper Lithgow |Lennart Brewitz |Kirsten Christensen

αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes† Epoxides are an established class of electrophilic alkylating agents that react with nucleophilic protein residues. We report αβ,α′β′-diepoxyketones (DEKs) as a new type of mechanism-based inhibitors of nucleophilic cysteine enzymes.

May 30, 2023 | pubs.rsc.org | Mariska de Munnik |Pauline A. Lang |Robert Bates |Monica Cacho

High-Throughput Screen with the L,D-transpeptidase LdtMt2 of Mycobacterium tuberculosis Reveals Novel Classes of Covalently Reacting Inhibitors Mariska de Munnik,   Pauline A. Lang,   Francisco De Dios Anton,   Monica Cacho,   Robert H.