Jayanth Venkatarama Reddy

Dec 29, 2024 | analyticalsciencejournals.onlinelibrary.wiley.com | Jayanth Venkatarama Reddy |Thomas Leibiger |Sumit Kumar Singh

Supporting Information Filename Description bit28916-sup-0001-Supplementary_information.docx2.3 MB Supporting information. References , , , et al. 2019. “Mechanistic Reconstruction of Glycoprotein Secretion Through Monitoring of Intracellular N-Glycan Processing.” Science Advances 5, no. 11: eaax8930. https://doi.org/10.1126/sciadv.aax8930. , and . 2016. “Glycosylation of Monoclonal Antibody Products: Current Status and Future Prospects.” Biotechnology Progress 32, no.

Dec 9, 2024 | pubs.acs.org | Tianxin Zhang |Jayanth Venkatarama Reddy |Ashwin Dravid |Lateef Aliyu

IntroductionClick to copy section linkSection link copied!A biopharmaceutical is a pharmaceutical drug product manufactured in, extracted from, or partially synthesized from biological sources. The biological production of macro-molecular products (primarily proteins) requires specific cell lines that meet product requirements for translational fidelity and post-translational modifications, particularly in the biopharmaceutical domain.

Dec 9, 2024 | dx.doi.org | Tianxin Zhang |Ashwin Dravid |Jayanth Venkatarama Reddy |Lateef Aliyu

Aug 2, 2024 | biorxiv.org | Sumit Kumar Singh |Kelvin Lee |Jayanth Venkatarama Reddy |Thomas Leibiger

AbstractChinese Hamster Ovary (CHO) cells were grown at different bioreactor pH conditions to detail how bioreactor pH affects cell metabolism and site-specific N-linked glycosylation of the produced broadly neutralizing anti-HIV IgG monoclonal antibody VRC01. The data show that pH affects cell growth, glucose/lactate metabolism, IgG production rates, nonessential amino acid metabolism and ammonia accumulation.