Thomas Leibiger

Dec 29, 2024 | analyticalsciencejournals.onlinelibrary.wiley.com | Jayanth Venkatarama Reddy |Thomas Leibiger |Sumit Kumar Singh

Supporting Information Filename Description bit28916-sup-0001-Supplementary_information.docx2.3 MB Supporting information. References , , , et al. 2019. “Mechanistic Reconstruction of Glycoprotein Secretion Through Monitoring of Intracellular N-Glycan Processing.” Science Advances 5, no. 11: eaax8930. https://doi.org/10.1126/sciadv.aax8930. , and . 2016. “Glycosylation of Monoclonal Antibody Products: Current Status and Future Prospects.” Biotechnology Progress 32, no.

Aug 2, 2024 | biorxiv.org | Sumit Kumar Singh |Kelvin Lee |Jayanth Venkatarama Reddy |Thomas Leibiger

AbstractChinese Hamster Ovary (CHO) cells were grown at different bioreactor pH conditions to detail how bioreactor pH affects cell metabolism and site-specific N-linked glycosylation of the produced broadly neutralizing anti-HIV IgG monoclonal antibody VRC01. The data show that pH affects cell growth, glucose/lactate metabolism, IgG production rates, nonessential amino acid metabolism and ammonia accumulation.