Jean-Laurent Casanova

Nov 20, 2024 | nature.com | Shen-Ying Zhang |Jean-Laurent Casanova

AbstractHerpes simplex virus 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in humans. It is life-threatening and has a first peak of incidence in childhood, during primary infection. Children with HSE are not particularly prone to other infections, including HSV-1 infections of tissues other than the brain.

Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova |Ann-Hwee Lee

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Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova

In Fig. 1B of the Report “Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase” (5 October 2001, p. 173), an image of the positive controls showing ubiquitination of cyclin E/Cdk2 in lanes 10, 11, and 12 was mistakenly used in the positive control lanes 4, 5, and 6 during figure assembly. Both experiments were performed under identical conditions.

Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova |Mattia Maroso

Neuroscience Wiring principles in the human cortexMattia MarosoConnections between pyramidal neurons, shown here in an artistic illustration, likely contribute to humans’ distinctive cognitive abilities. PHOTO: SCIENCE PHOTO LIBRARY/ALAMY STOCK PHOTOUnderstanding properties and connectivity of neurons in the human brain cortex is critical for understanding the mechanisms supporting cognitive functions. Most of our current knowledge of the cortical synaptic structure is derived from rodent studies.

Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova |Caroline Ash

Climate Teeth record climateCaroline AshA mother and baby orangutan drinking water in Tanjung Puting, BorneoPHOTO: STEVE BLOOM IMAGES/ALAMY STOCK PHOTOAccreting materials, such as coral reefs, tree rings, sediments, and ice, are a source material for data on past environmental variation. Likewise, other accreting materials, such as tooth enamel, could provide a record of the climate experienced by individuals.