Jean-Laurent Casanova

1 month ago | jci.org | Svenja Weiss |Hung-Mo Lin |Eric Acosta |Natalia L. Komarova |Ping Chen |Dominik Wodarz | +10 more

AbstractEarly antibody therapy can prevent severe SARS-CoV-2 infection (COVID-19). However, the effectiveness of COVID-19 convalescent plasma (CCP) therapy in treating severe COVID-19 remains inconclusive. To test a hypothesis that some CCP units are associated with a coagulopathy hazard in severe disease that offsets its benefits, we tracked 304 CCP units administered to 414 hospitalized COVID-19 patients to assess their association with the onset of unfavorable post-transfusion D-dimer trends.

Nov 20, 2024 | nature.com | Shen-Ying Zhang |Jean-Laurent Casanova

AbstractHerpes simplex virus 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in humans. It is life-threatening and has a first peak of incidence in childhood, during primary infection. Children with HSE are not particularly prone to other infections, including HSV-1 infections of tissues other than the brain.

Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova |Ann-Hwee Lee

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Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova

In Fig. 1B of the Report “Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase” (5 October 2001, p. 173), an image of the positive controls showing ubiquitination of cyclin E/Cdk2 in lanes 10, 11, and 12 was mistakenly used in the positive control lanes 4, 5, and 6 during figure assembly. Both experiments were performed under identical conditions.

Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova |Mattia Maroso

Neuroscience Wiring principles in the human cortexMattia MarosoConnections between pyramidal neurons, shown here in an artistic illustration, likely contribute to humans’ distinctive cognitive abilities. PHOTO: SCIENCE PHOTO LIBRARY/ALAMY STOCK PHOTOUnderstanding properties and connectivity of neurons in the human brain cortex is critical for understanding the mechanisms supporting cognitive functions. Most of our current knowledge of the cortical synaptic structure is derived from rodent studies.