Jean-Laurent Casanova

2 months ago | jci.org | Svenja Weiss |Hung-Mo Lin |Eric Acosta |Natalia L. Komarova |Ping Chen |Dominik Wodarz | +10 more

AbstractEarly antibody therapy can prevent severe SARS-CoV-2 infection (COVID-19). However, the effectiveness of COVID-19 convalescent plasma (CCP) therapy in treating severe COVID-19 remains inconclusive. To test a hypothesis that some CCP units are associated with a coagulopathy hazard in severe disease that offsets its benefits, we tracked 304 CCP units administered to 414 hospitalized COVID-19 patients to assess their association with the onset of unfavorable post-transfusion D-dimer trends.

2 months ago | cell.com | Rocio Vicario |Stamatina Fragkogianni |Maria Pokrovskii |Carina Meyer |Estibaliz Lopez-Rodrigo |Yang Hu | +31 more

Keywords Neurodegeneration MAPK pathway microglia hippocampus brainstem resident macrophages Introduction Langerhans cell histiocytosis (LCH)1 and Erdheim-Chester disease (ECD)2,3 are rare clonal myeloid disorders, with an estimated incidence of ∼5 cases per million people per year.4 They are sometimes co-diagnosed in the same patients,5 and both associated with a high prevalence of the BRAFV600E mutation1,2,3,6,7,8 as well as an increased risk of neurodegenerative disease...

Nov 20, 2024 | nature.com | Shen-Ying Zhang |Jean-Laurent Casanova

AbstractHerpes simplex virus 1 (HSV-1) encephalitis (HSE) is the most common sporadic viral encephalitis in humans. It is life-threatening and has a first peak of incidence in childhood, during primary infection. Children with HSE are not particularly prone to other infections, including HSV-1 infections of tissues other than the brain.

Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova |Ann-Hwee Lee

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Apr 18, 2024 | science.org | Naïma Jesse Madi |Bowen Tan |Jean-Laurent Casanova

In Fig. 1B of the Report “Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase” (5 October 2001, p. 173), an image of the positive controls showing ubiquitination of cyclin E/Cdk2 in lanes 10, 11, and 12 was mistakenly used in the positive control lanes 4, 5, and 6 during figure assembly. Both experiments were performed under identical conditions.