Jennifer Jordan

Dec 31, 2024 | bmcgenomics.biomedcentral.com | Silvana Gaudieri |Sean Hood |Allison Miller |Jennifer Jordan |Laura Thornton |Cynthia Bulik | +4 more

We performed a targeted nanopore sequencing proof-of-principle study in a small cohort of AN cases (n = 10) and successfully characterised the regions surrounding the eight AN risk loci, at nucleotide resolution. Target regions were clearly enriched in the sequence data obtained, relative to off-target regions, showing higher average read lengths and coverages (Table 2; Supplementary Fig. 1).

Feb 12, 2024 | ahajournals.org | Kerryn Reding |Jennifer Jordan

REFERENCES1. Khedagi AM, Bello NA. Hypertensive disorders of pregnancy.Cardiol Clin. 2021; 39:77–90. doi: 10.1016/j.ccl.2020.09.005CrossrefMedlineGoogle Scholar2. Azeez O, Kulkarni A, Kuklina EV, Kim SY, Cox S. Hypertension and diabetes in non-pregnant women of reproductive age in the United States.Prev Chronic Dis. 2019; 16:E146. doi: 10.5888/pcd16.190105CrossrefMedlineGoogle Scholar3. Cameron NA, Petito LC, Shah NS, Perak AM, Catov JM, Bello NA, Capewell S, O’Flaherty M, Lloyd-Jones DM, Greenland P, .

Oct 16, 2023 | biorxiv.org | Caroline Miller |Jennifer Jordan |Alexandra Thomas |Giselle C. Meléndez

AbstractBackground: There is considerable focus on developing strategies for identifying subclinical cardiac decline prior to cardiac failure. Myocardial tissue elasticity changes may precede irreversible cardiac damage, providing promise for an early biomarker for cardiac decline. Biomarker strategies are of particular interest in cardio-oncology due to cardiotoxic effects of anti-neoplastic therapies, particularly anthracycline-based chemotherapeutics.

Oct 1, 2023 | jacc.org | Moriah P. Bellissimo |Justin M. Canada |Jennifer Jordan |Amy C. Ladd

Introduction Substantial advancements in detection and treatment for women diagnosed with breast cancer (BC) have improved 5-year cancer-related survival to 90%.1 However, commonly used BC therapies, such as anthracycline-based chemotherapy (anthra-bC) and chest radiotherapy, have cardiotoxic side effects including injury to cardiac myocytes and other cells, increased oxidative stress, and reductions in left ventricular (LV) ejection fraction (LVEF), thereby accelerating the risk for...