Cynthia Bulik

Dec 31, 2024 | bmcgenomics.biomedcentral.com | Silvana Gaudieri |Sean Hood |Allison Miller |Jennifer Jordan |Laura Thornton |Cynthia Bulik | +4 more

We performed a targeted nanopore sequencing proof-of-principle study in a small cohort of AN cases (n = 10) and successfully characterised the regions surrounding the eight AN risk loci, at nucleotide resolution. Target regions were clearly enriched in the sequence data obtained, relative to off-target regions, showing higher average read lengths and coverages (Table 2; Supplementary Fig. 1).

Aug 22, 2024 | psiquiatria.com | Cynthia Bulik

Muchas personas con trastornos alimentarios y sus familiares están cada vez más informados sobre los avances científicos que pueden influir en el tratamiento y el pronóstico de estas enfermedades. Utilizan este conocimiento de manera efectiva para evaluar las opciones de tratamiento disponibles y abogar por una atención basada en la mejor evidencia posible. Esto les permite plantear preguntas complejas que muchos médicos a menudo no están completamente preparados para responder.

Mar 1, 2024 | cell.com | Laura M Huckins |Kristen J. Brennand |Cynthia Bulik

HighlightsFeeding and eating disorders (FEDs) are common and have been shown to be influenced by both genetic and environmental factors. Avoidant/restrictive food intake disorder, anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED) are all heritable and genome-wide association studies (GWASs) reveal both psychiatric and metabolic/anthropometric genetic risk factors for AN. GWASs for other FEDs are underway.

Feb 26, 2024 | nature.com | Clara Albiñana |Zhihong Zhu |Nis Borbye-Lorenzen |Kristin Skogstrand |Naomi R. Wray |Joana A. Revez | +7 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-36392-5, published online 15 February 2023The original version of this article contained an error in the second paragraph of the ‘Assay of DBP concentration’ section of the ‘Methods’, which incorrectly read ‘The lower and upper detection limits for DBP were 2.07 and 79.8 mg/L respectively’. The correct version states ‘2.07 µg/L’ in place of ‘2.07’. This has been corrected in both the PDF and HTML versions of the article.

Sep 1, 2023 | nature.com | Shahram Bahrami |Guy Hindley |Olav B. Smeland |Oleksandr Frei |Chun C. Fan |Srdjan Djurovic | +2 more

AbstractAnorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits have been reported, their shared genetic architecture is largely understudied.