Ayşe Demirkan

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.

Nov 6, 2023 | biorxiv.org | Ayşe Demirkan |Jenny van Dongen |Casey T. Finnicum |Harm Jan Westra

AbstractBoth gene methylation and the gut microbiome are partially determined by host genetics and partially by environment. We investigated the relations between gene methylation in blood and the abundance of common gut bacteria profiled by 16s rRNA gene sequencing in two population based Dutch cohorts: LifeLinesDeep (LLD, n = 616, discovery) and the Netherlands Twin Register (NTR, n = 296, replication).