-
Nov 25, 2024 | 
nature.com | Alex Sigal |Richard Neher |Richard Lessells
AbstractSARS-CoV-2 causes an acute respiratory tract infection that resolves in most people in less than a month. Yet some people with severely weakened immune systems fail to clear the virus, leading to persistent infections with high viral titres in the respiratory tract. In a subset of cases, persistent SARS-CoV-2 replication results in an accelerated accumulation of adaptive mutations that confer escape from neutralizing antibodies and enhance cellular infection.
-
Jul 11, 2024 | 
biorxiv.org | Marco Molari |Liam Shaw |Richard Neher
AbstractBacterial genomes primarily diversify via gain, loss, and rearrangement of genetic material in their flexible accessory genome. Yet the dynamics of accessory genome evolution are very poorly understood, in contrast to the core genome where diversification is readily described by mutations and homologous recombination. Here, we tackle this problem for the case of very closely related genomes. We comprehensively describe genome evolution within n=222 genomes of E.
-
Jul 5, 2024 | 
biorxiv.org | Richard Neher
AbstractContinuous phylogeographic inference is a popular method to reconstruct the spatial distribution of ancestral populations and estimate parameters of the dispersal process.
-
Feb 11, 2024 | 
arxiv.org | Richard Neher
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
-
Jan 3, 2024 | 
nature.com | Marek Basler |Petr Broz |Knut Drescher |Alexander Harms |Andreas Hierlemann |Sebastian Hiller | +11 more
In vitro models mimicking in-patient conditions have the potential to yield exciting opportunities for antibiotic research and revitalize future antibiotic discovery and development. Antibiotics have revolutionized modern medicine. However, their usefulness in treating bacterial infections and as prophylactics accompanying chemotherapy or surgery is under threat by the rise of antibiotic-resistant bacteria.
-
Nov 29, 2023 | 
biorxiv.org | Liam Shaw |Richard Neher
AbstractUnderstanding the evolution of mobile genes is important for understanding the spread of antimicrobial resistance (AMR). Many clinically important AMR genes have been mobilized by mobile genetic elements (MGEs) on the kilobase scale, such as integrons and transposons, which can integrate into both chromosomes and plasmids and lead to rapid spread of the gene through bacterial populations.
-
Sep 11, 2023 | 
nature.com | Mariana Duque |Daniel Sobral |Cornelius Roemer |Richard Neher |Megan O’Driscoll |Alexandra Nunes | +10 more
AbstractPathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics.
-
Aug 16, 2023 | 
einpresswire.com | Richard Neher
City Slams is the flagship program of Conga SportsSportsEdTV exists to help athletes, coaches, and parents LEARN, WIN, and CELEBRATE. LOS ANGELES, CALIFORNIA, UNITED STATES, August 16, 2023/ EINPresswire.com/ -- Conga Sports Inc, a provider of innovative racquet sports programs welcomes SportsEdTV as a Strategic Partner of its CITY SLAMS tournaments series. The CITY SLAMS tournament series will see teams of recreational tennis players compete for their city and community.
-
Aug 7, 2023 | 
biorxiv.org | Liam Shaw |Richard Neher
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
-
Jun 6, 2023 | 
biorxiv.org | Jesse Bloom |Richard Neher
New Results doi: https://doi.org/10.1101/2023.01.30.526314 ABSTRACTKnowledge of the fitness effects of mutations to SARS-CoV-2 can inform assessment of new variants, design of therapeutics resistant to escape, and understanding of the functions of viral proteins.
