Jianhua Luo

Oct 2, 2024 | nature.com | Xinchen Lv |Yuanyuan Zhang |Jianhua Luo |Liang Tao

AbstractClostridioides difficile toxin B (TcdB) is the key virulence factor accounting for C. difficile infection-associated symptoms. Effectively neutralizing different TcdB variants with a universal solution poses a significant challenge. Here we present the de novo design and characterization of pan-specific mini-protein binders against major TcdB subtypes.