Zhengyu Gao

Jul 7, 2024 | nature.com | Laixing Zhang |Hao Wang |Jianwei Zeng |Zhengyu Gao |Jiawei Wang |Yi Zhang | +1 more

AbstractClustered regularly interspaced short palindromic repeats (CRISPR)–Cas systems are prokaryotic adaptive immune systems against invading phages and other mobile genetic elements. Notably, some phages, including the Vibrio cholerae-infecting ICP1 (International Center for Diarrheal Disease Research, Bangladesh cholera phage 1), harbor CRISPR–Cas systems to counteract host defenses.

Oct 15, 2023 | nature.com | Zhengyu Gao |Long Zhang

Recently, a study published in Science by Liu et al.1 presented compelling evidence demonstrating that upon translocation to the Golgi apparatus, STING (Stimulator of Interferon Genes) serves as a direct mediator for proton release into the cytosol, thereby instigating non-canonical LC3B (light-chain 3B) lipidation and NLRP3 (NOD-like receptor family pyrin domain–containing 3) inflammasome activation (Fig. 1).