Jianyu Yang

Aug 8, 2024 | mdpi.com | Yutong Wang |Jianyu Yang

1. IntroductionChina’s property reform in the late 20th century precipitated the rapid growth of the real estate sector. Bolstered by vigorous urbanization and substantial governmental backing, real estate swiftly emerged as a cornerstone industry that was crucial for national economic advancement [1].

Jul 16, 2024 | cell.com | Cheng Xu |Holly E. Kleinschmidt |Jianyu Yang |Erik M Leith

Highlights•Systematic dissection of genetic rules underlying FOXA1 binding specificity•FOXA1 binding is strongly promoted by co-binding TFs AP-1 and CEBPB•Chromatin context (e.g., heterochromatin) plays a minor role in FOXA1 binding•AP-1 is partially responsible for cell-type-specific binding of FOXA1SummaryDespite the unique ability of pioneer factors (PFs) to target nucleosomal sites in closed chromatin, they only bind a small fraction of their genomic motifs.

May 16, 2024 | mdpi.com | Wei Liao |Weijun Yang |Jianyu Yang

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticlebyWei LiaoSciProfilesScilitPreprints.orgGoogle Scholar *, Weijun YangSciProfilesScilitPreprints.orgGoogle Scholar and Jianyu YangSciProfilesScilitPreprints.orgGoogle Scholar School of Civil Engineering, Changsha University of Science & Technology, Changsha 410114, China*Author to whom correspondence should be addressed.

Apr 7, 2024 | mdpi.com | Qian Zhang |Linlin Hu |Jianyu Yang |Pengfei Guo

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Nov 11, 2023 | biorxiv.org | Cheng Xu |Holly E. Kleinschmidt |Jianyu Yang |Erik M Leith

AbstractDespite the unique ability of pioneer transcription factors (PFs) to target nucleosomal sites in closed chromatin, they only bind a small fraction of their genomic motifs. The underlying mechanism of this selectivity is not well understood. Here, we design a high-throughput assay called ChIP-ISO to systematically dissect sequence features affecting the binding specificity of a classic PF, FOXA1.