Jiarui Ding

Jan 14, 2025 | biorxiv.org | Sarah Chen |Aviv Regev |Anne Condon |Jiarui Ding

AbstractSingle-cell RNA-seq data have provided new insights into intracellular and intercellular processes. Because multiple processes are active in each cell simultaneously, such as its cell type program, differentiation, the cell cycle, and environmental responses, their respective signals can confound one another, requiring methods that can separate and filter different complex biological signals.

Apr 17, 2024 | nature.com | Jiarui Ding |John Garber |Grace Carter |Toni Delorey |Orit Rozenblatt-Rosen |Daniel Graham | +2 more

AbstractCoordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from the esophageal mucosa of 7 healthy and 15 EoE participants, revealing 60 cell subsets and functional alterations in cell states, compositions, and interactions that highlight previously unclear features of EoE.