John Garber

Apr 17, 2024 | nature.com | Jiarui Ding |John Garber |Grace Carter |Toni Delorey |Orit Rozenblatt-Rosen |Daniel Graham | +2 more

AbstractCoordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from the esophageal mucosa of 7 healthy and 15 EoE participants, revealing 60 cell subsets and functional alterations in cell states, compositions, and interactions that highlight previously unclear features of EoE.