Yun Wang

3 weeks ago | biorxiv.org | Jie Zhang |Wenxuan Wu |Yun Wang |Youping Zhang

AbstractDespite the high efficacy of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) in treating acute promyelocytic leukemia (APL), approximately 10-20% of patients develop drug resistance due to mutations in PML-RARα and other factors. Here, it is demonstrated that inhibiting USP2 with ML364 or silencing USP2 reduces PML-RARα protein levels in both ATRA-sensitive and -resistant APL cells, an effect reversed by proteasome inhibition.

Nov 15, 2024 | mdpi.com | Yutao Chen |Yun Wang |Yubin zhao

1. IntroductionOver the last decade, a wide array of indoor positioning technologies has emerged, and their widespread acceptance and application across society are increasing [1,2,3]. Currently, the most utilized indoor positioning technologies encompass Wi-Fi [4,5,6], Bluetooth low energy (BLE) [7,8,9], and ultra-wide band (UWB) [10,11,12,13].

Oct 21, 2024 | mdpi.com | Ying Fu |Zhaohan Wang |Yun Wang

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Oct 7, 2024 | cell.com | Biomimetic Drugs |Yun Wang

Research topic(s) CP: Neuroscience CP: Developmental biology Introduction The chromodomain Y-like (CDYL) protein, comprising an amino-terminal canonical chromodomain and a carboxy-terminal enoyl-coenzyme A hydratase/isomerase catalytic domain, assumes crucial functions in gene repression.1 Previous studies have demonstrated that CDYL promotes the establishment and propagation of trimethylation of histone H3 at lysine 27 (H3K27me3) on chromatin and mediates the interaction between G9a and...

Sep 28, 2024 | mdpi.com | Yun Wang

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Yun Wang Yun Wang Scilit Preprints.org Google Scholar 1,2 1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China 2Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai 200433, China Brain Sci.