Jinjie Duan

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Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD - Nature Mental Health

Jul 16, 2024 | nature.com | Jinjie Duan |Daniel F Levey |G. Bragi Walters |Emma Johnson |Arpana Agrawal |Joel Gelernter | +2 more

AbstractCannabis use disorder (CUD) and cannabis use (CU) are prevalent conditions co-occurring with attention-deficit hyperactivity disorder (ADHD). Here we report results from a cross-disorder genome-wide association study of ADHD and CUD or CU. We identified 36 concordant genome-wide significant loci for ADHD–CUD and ten loci for ADHD–CU. DRD2 was identified as an ADHD–CUD risk gene.
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity - Nature Communications

Dec 9, 2023 | nature.com | Xu Zhang |Yi Zhu |Jinjie Duan

AbstractAging is a major risk factor for metabolic disorders. Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signaling molecules in metabolic processes. Nonetheless, their effects on age-related liver steatosis remain unknown. Here we show that senescent liver cells induce liver steatosis in a paracrine manner.

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