Daniel F Levey

Aug 15, 2024 | digitalcommons.library.tmc.edu | Daniel F Levey |Marco Galimberti |Joseph D. Deak |Frank R. Wendt

As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.

Jul 16, 2024 | nature.com | Jinjie Duan |Daniel F Levey |G. Bragi Walters |Emma Johnson |Arpana Agrawal |Joel Gelernter | +2 more

AbstractCannabis use disorder (CUD) and cannabis use (CU) are prevalent conditions co-occurring with attention-deficit hyperactivity disorder (ADHD). Here we report results from a cross-disorder genome-wide association study of ADHD and CUD or CU. We identified 36 concordant genome-wide significant loci for ADHD–CUD and ten loci for ADHD–CU. DRD2 was identified as an ADHD–CUD risk gene.

May 20, 2024 | medrxiv.org | Anya Topiwala |Daniel F Levey |Hang Zhou |Joseph D. Deak

The authors have declared no competing interest. This research used data from the Million Veteran Program and was supported by funding from the Department of Veterans Affairs Office of Research and Development, Million Veteran Program Grant #I01CX001849, and the VA Cooperative Studies Program (CSP) study #575B, and MVP025. This publication does not represent the views of the Department of Veterans Affairs or the United States Government. AT is supported by the Wellcome Trust (216462/Z/19/Z).

Feb 25, 2024 | nature.com | Max Lam |Jimmy Liu |Daniel F Levey |Joel Gelernter |Murray B. Stein |Ellen A. Tsai | +3 more

AbstractNearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present whole-exome sequencing analyses of depression with seven different definitions based on survey, questionnaire, and electronic health records in 320,356 UK Biobank participants.

Jan 4, 2024 | nature.com | Xiangrui Meng |Daniel F Levey |Dora Koller |Mark Adams |Miguel E. Rentería |Dan Stein | +42 more

AbstractMost genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%).