Arpana Agrawal

Jul 16, 2024 | nature.com | Jinjie Duan |Daniel F Levey |G. Bragi Walters |Emma Johnson |Arpana Agrawal |Joel Gelernter | +2 more

AbstractCannabis use disorder (CUD) and cannabis use (CU) are prevalent conditions co-occurring with attention-deficit hyperactivity disorder (ADHD). Here we report results from a cross-disorder genome-wide association study of ADHD and CUD or CU. We identified 36 concordant genome-wide significant loci for ADHD–CUD and ten loci for ADHD–CU. DRD2 was identified as an ADHD–CUD risk gene.

Dec 7, 2023 | nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more

AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).

Dec 7, 2023 | nature.com | Hang Zhou |Rachel L. Kember |Joseph D. Deak |Travis T. Mallard |Jiayi Xu |Emma Johnson | +18 more

AbstractProblematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N = 903,147; African, N = 122,571; Latin American, N = 38,962; East Asian, N = 13,551; and South Asian, N = 1,716 ancestries).

Nov 20, 2023 | nature.com | Daniel F Levey |Marco Galimberti |Joseph D. Deak |Dora Koller |Emma Johnson |Mahantesh Biradar | +12 more

AbstractAs recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.