Jinshan Zhang

Oct 26, 2024 | mdpi.com | Tao Lin Sun |Xin Wang |Jinshan Zhang |Lan Wang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Oct 22, 2024 | science.org | Teresa Rosenlehner |Jinshan Zhang |Annalisa M. VanHook |Yawen Zhao

Editor’s summaryThe appetite-stimulating hormone ghrelin promotes hepatic lipid accumulation. Zhang et al. investigated the regulation of hepatic lipid homeostasis by Piezo1, a mechanosensitive ion channel that is activated when food ingestion stretches the stomach and that suppresses ghrelin production. Mice lacking Piezo1 in ghrelin-producing cells in the stomach developed hepatic steatosis, which was reversed by pharmacologically blocking the ghrelin receptor.

Oct 22, 2024 | science.org | Teresa Rosenlehner |Jinshan Zhang |Annalisa M. VanHook

When a nuclear-replicating virus enters a host cell, the viral capsid docks onto the nuclear pore complex (NPC) to deliver the viral genome to the nucleus. For some viruses, such as human immunodeficiency virus 1 (HIV-1), the entire capsid translocates into the nucleus; for other viruses, like herpes simplex virus 1 (HSV-1), only the genome is released into the nucleus.

Oct 22, 2024 | science.org | Teresa Rosenlehner |Jinshan Zhang |Annalisa M. VanHook |Stefanie Pennavaria

Editor’s summaryActivated T cells must ramp up ribosomal biogenesis in nucleoli to support protein synthesis required for proliferation. Rosenlehner et al. investigated the interplay among T cell receptor (TCR) signaling, ribosomal biosynthesis, and mTORC1, a multiprotein complex implicated in cell growth and proliferation. mTORC1 was required for the rapid cell cycling of proliferating activated T cells.

Jun 16, 2024 | mdpi.com | Jinshan Zhang |Man Liu

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.