John Herndon

2 months ago | nature.com | Wagma Caravan |Kazuhito Sato |Xiang Li |Yize Li |John Herndon |Maxim N. Artyomov | +1 more

AbstractThere is a sex bias in the incidence and progression of many kidney diseases. To better understand such sexual dimorphism, we integrated data from six platforms, characterizing 76 kidney samples from 68 mice at six developmental and adult time points, creating a molecular atlas of the mouse kidney across the lifespan for both sexes.

2 months ago | digitalcommons.library.tmc.edu | Daniel Zhou |Reyka G. Jayasinghe |Siqi Chen |John Herndon

AbstractPancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, spatial transcriptomics and cellular imaging. Subpopulations of tumor cells exhibited signatures of proliferation, KRAS signaling, cell stress and epithelial-to-mesenchymal transition.

Nov 20, 2024 | 110forchrist.com | John Herndon

By John HerndonLEXINGTON – It didn’t take long to find out something was refreshingly different about Sayre football. I had written about the Spartans for some other writing gigs I accept each year, but since those had been summer previews, I’d gotten information through email or through springtime interviews.

Oct 30, 2024 | nature.com | Reyka G. Jayasinghe |Michael Iglesia |John Herndon |Austin N. Southard-Smith |Jacqueline L. Mudd |Alla Karpova | +16 more

AbstractTo study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined ‘tumour microregions’ as spatially distinct cancer cell clusters separated by stromal components.

Oct 16, 2024 | 110forchrist.com | John Herndon

By John Herndon, 110forChrist.comGEORGETOWN, Ky. – I love those Friday Night Lights. I’m not talking about H.G. Bissinger’s classic book about the Odessa (Tex.) Permian Panthers. Nor am I referring to  the movie adaptation – although it was mighty good – or the TV show the book inspired. I am talking real Friday Night Lights, that small town fall ritual that is as American as it gets. It’s as much a part of American heritage as John Deere or Johnny Cash.