John Herndon

Lawrenceburg

Freelance Writer at Freelance

Writing about Jesus glorified! Minister Mackville Christian Church. Former sports editor. Still writing at https://t.co/7SAzdJkyrS and https://t.co/P6Oz0VLgrj.

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Articles

Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan - Nature Genetics

1 month ago | nature.com | Wagma Caravan |Kazuhito Sato |Xiang Li |Yize Li |John Herndon |Maxim N. Artyomov | +1 more

AbstractThere is a sex bias in the incidence and progression of many kidney diseases. To better understand such sexual dimorphism, we integrated data from six platforms, characterizing 76 kidney samples from 68 mice at six developmental and adult time points, creating a molecular atlas of the mouse kidney across the lifespan for both sexes.
Spatially Restricted Drivers and Transitional Cell Populations Cooperate With the Microenvironment in Untreated and Chemo-Resistant Pancreatic Cancer

1 month ago | digitalcommons.library.tmc.edu | Daniel Zhou |Reyka G. Jayasinghe |Siqi Chen |John Herndon

AbstractPancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, spatial transcriptomics and cellular imaging. Subpopulations of tumor cells exhibited signatures of proliferation, KRAS signaling, cell stress and epithelial-to-mesenchymal transition.
NEW POWER SAYRE TAKES CLASSICAL APPROACH TO SUCCESS

Nov 20, 2024 | 110forchrist.com | John Herndon

By John HerndonLEXINGTON – It didn’t take long to find out something was refreshingly different about Sayre football. I had written about the Spartans for some other writing gigs I accept each year, but since those had been summer previews, I’d gotten information through email or through springtime interviews.
Tumour evolution and microenvironment interactions in 2D and 3D space - Nature

Oct 30, 2024 | nature.com | Reyka G. Jayasinghe |Michael Iglesia |John Herndon |Austin N. Southard-Smith |Jacqueline L. Mudd |Alla Karpova | +16 more

AbstractTo study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined ‘tumour microregions’ as spatially distinct cancer cell clusters separated by stromal components.
SCOTT COUNTY FRIDAY NIGHTS SHINE EVEN BRIGHTER

Oct 16, 2024 | 110forchrist.com | John Herndon

By John Herndon, 110forChrist.comGEORGETOWN, Ky. – I love those Friday Night Lights. I’m not talking about H.G. Bissinger’s classic book about the Odessa (Tex.) Permian Panthers. Nor am I referring to the movie adaptation – although it was mighty good – or the TV show the book inspired. I am talking real Friday Night Lights, that small town fall ritual that is as American as it gets. It’s as much a part of American heritage as John Deere or Johnny Cash.
Anderson County Schools celebrate inducting their first class into the Anderson County Athletics Hall of Fame

Sep 12, 2024 | pmg-ky1.com | John Herndon
Lexington Christian plays to audience of one

Sep 11, 2024 | 110forchrist.com | John Herndon

By John Herndon, 110forChrist.comLEXINGTON – The size of the crowd doesn’t matter to Lexington Christian Academy football coach Doug Charles. He wants the Eagles to have the same mindset every Friday night. They are playing for an Audience of One. And that’s all that matters to Charles, who is in his sixth season leading one of Kentucky’s best football programs. Walk into the Eagles’ locker room and you are immediately reminded that they are to play for the Audience of One.
‘Win or lose, I just hope to glorify You’

Feb 6, 2024 | 110forchrist.com | John Herndon

By John Herndon, 110forChrist.comCRESTWOOD, Ky. – Not many expected South Oldham to be where the Dragons currently are heading toward March Madness, but that’s one of the things that makes high school basketball so special. When the 2023-34 season tipped off, few figured that South Oldham would be among the serious contenders for the Eighth Region championship. It wasn’t that the Dragons weren’t supposed to be in for a long season.
Bardstown rally falls short at Franklin County

Nov 22, 2023 | pmg-ky2.com | John Herndon

FRANKFORT — Tradition can be measured by more than championships. Bardstown proved that on Friday night. Down 37-7 at the half and on the verge of seeing the running clock, the Tigers looked inside their hearts and pulled up something they hadn’t shown in the first 24 minutes. In the end, Bardstown still came up short as host Franklin County stayed unbeaten with a 37-29 win in a Class 4A regional championship game played in light rain at Benny Watkins Field.
Epigenetic regulation during cancer transitions across 11 tumour types - Nature

Nov 1, 2023 | nature.com | Alla Karpova |Yize Li |Austin N. Southard-Smith |Michael Iglesia |Reyka G. Jayasinghe |Matthew Wyczalkowski | +17 more

AbstractChromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis1,2,3,4. Although the genetic contributions to oncogenic transitions have been investigated, epigenetic drivers remain less understood.