Maxim N. Artyomov

4 days ago | nature.com | Wagma Caravan |Kazuhito Sato |Xiang Li |Yize Li |John Herndon |Maxim N. Artyomov | +1 more

AbstractThere is a sex bias in the incidence and progression of many kidney diseases. To better understand such sexual dimorphism, we integrated data from six platforms, characterizing 76 kidney samples from 68 mice at six developmental and adult time points, creating a molecular atlas of the mouse kidney across the lifespan for both sexes.

Mar 13, 2024 | nature.com | Ambra Villani |Geoffrey Nelson |Seth Goldman |Maxim N. Artyomov |Rochelle M. Ellison |Yitan Chen | +1 more

AbstractDuring development, inflammation or tissue injury, macrophages may successively engulf and process multiple apoptotic corpses via efferocytosis to achieve tissue homeostasis1. How macrophages may rapidly adapt their transcription to achieve continuous corpse uptake is incompletely understood.

Jan 10, 2024 | nature.com | Mykyta Artomov |Alexander Loboda |Maxim N. Artyomov

AbstractAcquiring a sufficiently powered cohort of control samples matched to a case sample can be time-consuming or, in some cases, impossible. Accordingly, an ability to leverage genetic data from control samples that were already collected elsewhere could dramatically improve power in genetic association studies. Sharing of control samples can pose significant challenges, since most human genetic data are subject to strict sharing regulations.