Joint Diseases

Sep 17, 2024 | cell.com | Joint Diseases

Main textDiabetes mellitus, especially type 2 diabetes, poses complex challenges to bone health.22. Bonds, D.E. ∙ Larson, J.C. ∙ Schwartz, A.V. ... Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational StudyJ. Clin. Endocrinol. Metab. 2006; 91:3404-3410 Paradoxically, diabetes patients often experience fragile fractures despite normal or higher bone mineral density (BMD),33. Hofbauer, L.C. ∙ Busse, B. ∙ Eastell, R. ...

Jun 5, 2024 | link.springer.com | Shanghai Jiaotong |Shanghai Jiao Tong |Joint Diseases

AbstractThe chemokine CX3CL1 has been reported to play an important role in optic nerve protection, but the underlying mechanism is still unclear. CX3CR1, the only receptor of CX3CL1, is specifically expressed on retinal microglia, whose activation plays a role in the pathological process of optic nerve injury. This study aimed to evaluate whether CX3CL1 exerts optic neuroprotection by affecting the activation of microglia by combining with CX3CR1.

Feb 1, 2024 | aacrjournals.org | Joint Diseases |Hong Kong Baptist

Mar 28, 2023 | cell.com | Masahiro Nakajima |Joint Diseases |Masaru Koido |Long Guo

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common intractable disease that causes spinal stenosis and myelopathy. We have previously conducted genome-wide association studies for OPLL and identified 14 significant loci, but their biological implications remain mostly unclear. Here, we examined the 12p11.22 locus and identified a variant in the 5′ UTR of a novel isoform of CCDC91 that was associated with OPLL.