Jonathan Sussman

3 weeks ago | jamanetwork.com | Omar Elghawy |Jonathan Sussman |Austin Yang |Colin Thomas

Pembrolizumab in Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphoma (CTCL). Recent clinical trials have investigated immune checkpoint inhibitors (ICIs) as monotherapy or combination therapies for MF/SS with mixed results.1-3 Clinical data for ICIs in CTCL are sparse, limited primarily to case reports or small case series.

Dec 11, 2024 | mdpi.com | Michael Wang |Jonathan Sussman |Jessica Xu |Reema Patel

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Jul 26, 2024 | onlinelibrary.wiley.com | Takeshi Katsuda |Jonathan Sussman |Kenneth S. Zaret |Ben Z. Stanger

INTRODUCTION Pioneer transcription factors (TFs) play a crucial role in cell fate decisions during embryonic development and cellular reprogramming via their unique ability to enact persistent epigenomic changes.[1, 2] The name “pioneer factor” derives from an ability to facilitate chromatin opening; whereas most TFs can bind to regions of chromatin that are already accessible, pioneer factors have an increased ability to bind to DNA regions that are embedded in nucleosomes (“closed...

Feb 14, 2023 | biorxiv.org | Jonathan Sussman |Kenji Ito |Takeshi Katsuda |Andrew Katznelson

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