Kenneth S. Zaret

Jul 26, 2024 | onlinelibrary.wiley.com | Takeshi Katsuda |Jonathan Sussman |Kenneth S. Zaret |Ben Z. Stanger

INTRODUCTION Pioneer transcription factors (TFs) play a crucial role in cell fate decisions during embryonic development and cellular reprogramming via their unique ability to enact persistent epigenomic changes.[1, 2] The name “pioneer factor” derives from an ability to facilitate chromatin opening; whereas most TFs can bind to regions of chromatin that are already accessible, pioneer factors have an increased ability to bind to DNA regions that are embedded in nucleosomes (“closed...

Nov 6, 2023 | cell.com | Kenneth S. Zaret

HighlightsPioneer factors can be master regulators of development. They are responsible for zygotic genome activation after fertilization and drive cell fate transitions during development. Pioneer factors bind nucleosomal DNA containing their DNA-binding motifs. The binding is mediated by the DNA-binding domain of the pioneer factor and via establishment of histone–pioneer factor interactions.

Jul 4, 2023 | cell.com | Jonathan Lerner |Andrew Katznelson |Kenneth S. Zaret

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