José Antonio Enríquez

Jan 13, 2025 | nature.com | Beatriz Cicuéndez |Juan Lopez |Juan López |Andrea Curtabbi |Javier Perez-Garcia |Daniel Jimenez-Blasco | +15 more

AbstractObesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples.

Apr 26, 2023 | nature.com | José Antonio Enríquez |Martin Picard

AbstractMitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological recalibrations. Given their multifunctional and malleable nature, the frequently used terms ‘mitochondrial function’ and ‘mitochondrial dysfunction’ are misleading misnomers that fail to capture the complexity of mitochondrial biology.