Joshua Ames

3 weeks ago | science.org | Sigal B. Kofman |Annalisa M. VanHook |Lan Chu |Joshua Ames

Editor’s summaryIn contrast with proliferating cells, the activation of the RHIM domain–containing kinase RIPK3 in neurons does not induce necroptosis but rather an antiviral transcriptional response. Kofman et al. investigated the molecular mechanisms underlying this response. In cortical neurons, the RIPK3-dependent transcriptional response required other RHIM domain–containing proteins, RIPK1 and TRIF, that are also critical for necroptosis in proliferating cells.

2 months ago | cell.com | Emmanuelle Genoyer |Jonathan Wilson |Joshua Ames |Caleb Stokes |Dante Moreno |Noa Etzyon | +2 more

Keywords West Nile virus RIG-I RIG-I-like receptors innate immunity antiviral response Introduction Flaviviruses are a global threat to public health, placing billions at risk of infection and causing over 400 million disease cases per year worldwide.1 The emerging neurotropic flavivirus, West Nile virus (WNV), is the leading cause of arboviral infections in the United States, with recurrent annual outbreaks, and poses an ever-expanding hazard as its vector range increases.2 During WNV...