Kohei Hasegawa

May 4, 2024 | sciencedirect.com | Supinda Bunyavanich |Kohei Hasegawa |Geoffroy Laumet |Eun-Kyung Kwon

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dry, pruritic skin.1 Several studies have described nocturnal increases in scratching behavior, suggesting a role for circadian rhythms in modulating symptom severity.2,3 Circadian rhythms underlie skin physiology, such as DNA repair, transepidermal water loss, and keratinocyte proliferation.4,5 Understanding the mechanisms underpinning nocturnal increases in itch could improve therapeutic precision.