Eun-Kyung Kwon

May 4, 2024 | sciencedirect.com | Supinda Bunyavanich |Kohei Hasegawa |Geoffroy Laumet |Eun-Kyung Kwon

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dry, pruritic skin.1 Several studies have described nocturnal increases in scratching behavior, suggesting a role for circadian rhythms in modulating symptom severity.2,3 Circadian rhythms underlie skin physiology, such as DNA repair, transepidermal water loss, and keratinocyte proliferation.4,5 Understanding the mechanisms underpinning nocturnal increases in itch could improve therapeutic precision.

Apr 23, 2024 | sciencedirect.com | Hazel Wilkie |Raif S. Geha |Eun-Kyung Kwon |Ga-Young Ban

Section snippetsStudy designThis phase 2, randomized, double-blind, placebo-controlled trial (NCT04444752) was conducted across 59 sites in the United States (38), China (9), Australia (8), and New Zealand (4). The trial comprised a 45-day screening period, a 16-week treatment period, and an 8-week follow-up period (see Fig E1 in this article’s Online Repository at www.jacionline.org).

Oct 2, 2023 | sciencedirect.com | Geoffroy Laumet |Ga-Young Ban |E. Le Poul |Eun-Kyung Kwon

Disturbances in gut microbiota composition may underpin Western lifestyle diseases. Because the gut microbiota is generally confined to the gut, attention has focused on the role of microbiota metabolites that may be transported through the blood. One of the main functions of the gut microbiota is fermentation of dietary fiber to produce SCFAs.1 SCFAs increase intestinal barrier integrity, thereby lessening the chance of LPS and bacterial leakage into the body.