Geoffroy Laumet

May 4, 2024 | sciencedirect.com | Supinda Bunyavanich |Kohei Hasegawa |Geoffroy Laumet |Eun-Kyung Kwon

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dry, pruritic skin.1 Several studies have described nocturnal increases in scratching behavior, suggesting a role for circadian rhythms in modulating symptom severity.2,3 Circadian rhythms underlie skin physiology, such as DNA repair, transepidermal water loss, and keratinocyte proliferation.4,5 Understanding the mechanisms underpinning nocturnal increases in itch could improve therapeutic precision.

Apr 9, 2024 | sciencedirect.com | Geoffroy Laumet

The immune system classically consists of 2 lines of defense, innate and adaptive, both of which interact with one another effectively to protect us against any pathogenic threats. Importantly, there is a diverse subset of cells known as innate-like T cells that act as a bridge between the innate and adaptive immune systems and are pivotal players in eliciting inflammatory immune responses.

Nov 1, 2023 | sciencedirect.com | Geoffroy Laumet

The use of human antibodies as biologic therapeutics has revolutionized patient care throughout fields of medicine. As our understanding of the many roles antibodies play within our natural immune responses continues to advance, so will the number of therapeutic indications for which an mAb will be developed. The great breadth of function, long half-life, and modular structure allow for nearly limitless therapeutic possibilities.

Nov 1, 2023 | sciencedirect.com | Laure Migayron |Katia Boniface |Geoffroy Laumet |Ryusuke Hayashi

Section snippetsNational Health Interview SurveyData from the National Health Interview Survey (NHIS), years 2011 to 2018, were used to perform the analyses. The NHIS is the longest-running nationwide survey collecting health information in the United States and uses a complex sampling strategy to produce a nationally representative, generalizable population each year.

Nov 1, 2023 | sciencedirect.com | Scott Smith |Geoffroy Laumet |Maxim A.X. Tollenaere |Hanne Norsgaard

Section snippetsOntogeny of TRM cells in the skinAs discussed later in this review, whether TRM arise from pluripotent effector T cells that enter tissues in response to the local environment and/or from a specific subset of circulating T cells in blood remains to be fully elucidated.