Konstanze F. Winklhofer

Jun 7, 2024 | mdpi.com | Verian Bader |Konstanze F. Winklhofer |Matthias Vorgerd |Hilal Cihankaya

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Apr 3, 2024 | biorxiv.org | Christopher Green |Konstanze F. Winklhofer |Adam Fletcher |Leo James

AbstractAntibody-dependent intracellular neutralisation (ADIN) promotes the rapid proteasomal degradation of viruses and other large substrates in the cytosol. It is dependent on detection of intracellular virus-bound antibodies by the Fc receptor and E3 ligase TRIM21, followed by disassembly of the virus by the unfoldase VCP/p97. It is not known how VCP is recruited to TRIM21. We performed a limited siRNA knock- down screen of known VCP adaptors to determine their involvement in ADIN.

Jul 12, 2023 | pubs.rsc.org | Sashary Ramos |Janine Kamps |Simone Pezzotti |Konstanze F. Winklhofer

Hydration makes a difference! How to tune protein complexes between liquid-liquid and liquid-solid phase separation. Understanding the mechanisms that dictate Liquid-Liquid Phase Separation (LLPS) and Liquid-Solid Phase Separation (LSPS) and the transition between the two are prominent challenges in biology and medicine.