Kory J. Lavine

Jan 1, 2025 | nature.com | Kory J. Lavine

AbstractMacrophages make up a substantial portion of the stromal compartment of the heart in health and disease. In the past decade, the origins of these cardiac macrophages have been established as two broad populations derived from either embryonic or definitive haematopoiesis and that can be distinguished by the expression of CC-motif chemokine receptor 2 (CCR2).

Aug 28, 2024 | nature.com | Kory J. Lavine

NEWS AND VIEWS 28 August 2024 After a heart attack, cardiac muscle cells at the border between injured and healthy tissue instigate an inflammatory response, which spreads to neighbouring cells and makes the heart wall vulnerable to tearing. Cardiovascular diseases are among the top causes of illness and death worldwide.

May 20, 2024 | ahajournals.org | Kory J. Lavine

REFERENCES1. Hill MC, Kadow ZA, Long H, Morikawa Y, Martin TJ, Birks EJ, Campbell KS, Nerbonne J, Lavine K, Wadhwa L, . Integrated multi-omic characterization of congenital heart disease.Nature. 2022; 608:181–191. doi: 10.1038/s41586-022-04989-3CrossrefMedlineGoogle Scholar2. Liu J, Ma P, Lai L, Villanueva A, Koenig A, Bean GR, Bowles DE, Glass C, Watson M, Lavine KJ, . Transcriptional and immune landscape of cardiac sarcoidosis.Circ Res. 2022; 131:654–669.

May 15, 2024 | jci.org | Thassio R. Mesquita |Eugenio Cingolani |Stephen Chelko |Kory J. Lavine

AbstractArrhythmogenic cardiomyopathy (ACM) is an inherited cardiac condition characterized by cardiac remodeling and life-threatening ventricular arrhythmias. In this issue of the JCI, Chelko, Penna, and colleagues mechanistically addressed the intricate contribution of immune-mediated injury in ACM pathogenesis.

Jul 3, 2023 | nature.com | Kory J. Lavine

Vascular inflammation is an established risk factor for atherosclerosis progression and associated outcomes. Single-cell RNA sequencing of carotid atherosclerotic plaques identifies a population of lipid-associated macrophages that may contribute to plaque inflammation and clinical events.