Kouichi Ozaki

Oct 3, 2024 | nature.com | Satoshi Koyama |Xiaoxi Liu |Yoshinao Koike |Keiko Hikino |Masaru Koido |Wei Li | +13 more

AbstractHuman genetic variants are associated with many traits through largely unknown mechanisms. Here, combining approximately 260,000 Japanese study participants, a Japanese-specific genotype reference panel and statistical fine-mapping, we identified 4,423 significant loci across 63 quantitative traits, among which 601 were new, and 9,406 putatively causal variants.

May 19, 2024 | nature.com | Xiaoxi Liu |Yoshinao Koike |Keiko Hikino |Yukihide Momozawa |Kouichi Ozaki |Hirotaka Watada | +2 more

AbstractSarcopenia is a common skeletal muscle disease in older people. Lower limb muscle strength is a good predictive value for sarcopenia; however, little is known about its genetic components. Here, we conducted a genome-wide association study (GWAS) for knee extension strength in a total of 3452 Japanese aged 60 years or older from two independent cohorts.

Jun 29, 2023 | nature.com | Daichi Shigemizu |Kouichi Ozaki

Ethics statementsThis study was approved by the ethics committee of the National Center for Geriatrics and Gerontology (NCGG). The design and performance of the current study involving human subjects were clearly described in a research protocol. All participation was voluntary, and all participants completed informed consent in writing before registering with the NCGG Biobank.