Landsteiner Laboratory

Dec 10, 2024 | onlinelibrary.wiley.com | Tamara Verkerk |Landsteiner Laboratory |Amsterdam UMC |Jasper Sanders

1 Introduction To establish an effective antitumor response, immune cell receptors work synergistically to mediate and fine-tune cellular responses. Functional interaction between receptors and their ligands is necessary to activate the right pro-inflammatory immune cells or inhibit suppressive cells for a specific, yet balanced immune response.

May 8, 2024 | onlinelibrary.wiley.com | Rick Kapur |Sanquin Research |Landsteiner Laboratory |Amsterdam UMC

Immune thrombocytopenia (ITP) is an acquired autoimmune disorder with an increased risk of bleeding due to a low number of platelets (<100 × 109/L).1 ITP results from an increased platelet destruction and decreased platelet production, which may clinically present with petechiae, purpura and mucosal bleedings, and in rare cases with intracranial bleedings.2 Typically, patients with ITP suffer from a reduced health-related quality of life, frequently impacted by fatigue.2 Several therapeutic...

Jan 4, 2024 | ashpublications.org | van der Velden |Sanquin Research |Landsteiner Laboratory |Amsterdam UMC

Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-related fatalities and, to date, is without available therapies. Here, we investigated the role of the complement system in TRALI. Murine anti–major histocompatibility complex class I antibodies were used in TRALI mouse models, in combination with analyses of plasma samples from patients with TRALI.

Jun 2, 2023 | ashpublications.org | Sanquin Research |Landsteiner Laboratory |Amsterdam UMC |van der Meulen

E-cadherin is a highly conserved transmembrane protein and a key component of epithelial cell adherence junctions that critically control tissue homeostasis.1-4 E-cadherin binding of β-catenin additionally links E-cadherin with Wnt/β-catenin signaling.5 In epithelia, E-cadherin is able to stabilize β-catenin by competing with adenomatous polyposis coli (APC) for β-catenin binding.6 APC is a component of the β-catenin destruction complex, which on binding induces phosphorylation and...