Sanquin Research

May 8, 2024 | onlinelibrary.wiley.com | Rick Kapur |Sanquin Research |Landsteiner Laboratory |Amsterdam UMC

Immune thrombocytopenia (ITP) is an acquired autoimmune disorder with an increased risk of bleeding due to a low number of platelets (<100 × 109/L).1 ITP results from an increased platelet destruction and decreased platelet production, which may clinically present with petechiae, purpura and mucosal bleedings, and in rare cases with intracranial bleedings.2 Typically, patients with ITP suffer from a reduced health-related quality of life, frequently impacted by fatigue.2 Several therapeutic...

Jan 4, 2024 | ashpublications.org | van der Velden |Sanquin Research |Landsteiner Laboratory |Amsterdam UMC

Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-related fatalities and, to date, is without available therapies. Here, we investigated the role of the complement system in TRALI. Murine anti–major histocompatibility complex class I antibodies were used in TRALI mouse models, in combination with analyses of plasma samples from patients with TRALI.

Jun 2, 2023 | ashpublications.org | Sanquin Research |Landsteiner Laboratory |Amsterdam UMC |van der Meulen

E-cadherin is a highly conserved transmembrane protein and a key component of epithelial cell adherence junctions that critically control tissue homeostasis.1-4 E-cadherin binding of β-catenin additionally links E-cadherin with Wnt/β-catenin signaling.5 In epithelia, E-cadherin is able to stabilize β-catenin by competing with adenomatous polyposis coli (APC) for β-catenin binding.6 APC is a component of the β-catenin destruction complex, which on binding induces phosphorylation and...

Apr 25, 2023 | frontiersin.org | Sanquin Research

Elisabeth Dovern1*, Bart Biemond1 and Erfan Nur1, 2 1Amsterdam University Medical Center, Netherlands 2Sanquin Research, Netherlands The final, formatted version of the article will be published soon. Receive an email when it is updated Pure red cell aplasia (PRCA) is a serious complication after ABO-mismatched allogeneic hematopoietic stem cell transplantation (HSCT).