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2 weeks ago | 
nature.com | Robert Baird |Andy Gardner |Laura Ross
AbstractDifferences in transmission and ploidy between sex chromosomes and autosomes drive divergent evolutionary trajectories, with sex chromosomes generally evolving faster. Because sex-linked genes are transmitted less frequently, they are under less efficient selection. Conversely, exposure of recessive mutations on haploid sex chromosomes creates more efficient selection. In most systems, these effects occur simultaneously and are confounded.
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Nov 11, 2024 | 
biorxiv.org | Katy M. Monteith |Laura Ross |Robert Baird |Maria Shlyakonova
AbstractSex determination mechanisms in insects are extraordinarily diverse, although most species have zygotic genotypic sex determination where sex is established by sex chromosomes upon fertilisation. Dark-winged fungus gnats (Diptera: Sciaridae) are a large and speciose family of flies where sex determination is a result of an unusual interplay of zygotic, maternal, and environmental factors.
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Oct 25, 2024 | 
biorxiv.org | Thomas Hitchcock |Robert Baird |Andy Gardner |Laura Ross
AbstractSex chromosomes differ from autosomes in both their ploidy and transmission genetics. Consequently, selection, mutation, and drift may act differently upon them, driving distinct patterns in genetic divergence, diversity, and gene content. Recently, researchers have begun to consider a wider set of organisms with non-standard inheritance and sex-determination systems, however in many cases we lack theory which extends to such cases.
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Oct 1, 2024 | 
jrheum.org | Julie McDonald |Laura Ross |Carolyn Wicks |Jennifer Philip
Examining the Case for Palliative Care in Patients With Systemic Sclerosis Julie C. McDonald, Laura Ross, Carolyn J. Wicks, Jennifer A.M. Philip The Journal of Rheumatology Oct 2024, 51 (10) 957-963; DOI: 10.3899/jrheum.2023-1251
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Jul 26, 2024 | 
jrheum.org | Julie McDonald |Laura Ross |Carolyn Wicks |Jennifer Philip
Examining the Case for Palliative Care in Patients With Systemic Sclerosis Julie C. McDonald, Laura Ross, Carolyn J. Wicks, Jennifer A.M. Philip The Journal of Rheumatology Jul 2024, jrheum.2023-1251; DOI: 10.3899/jrheum.2023-1251
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Jun 20, 2024 | 
digitalcommons.library.tmc.edu | Jessica Fairley |Dylan Hansen |Laura Ross |Susanna Proudman
To describe the clinical phenotype and prognosis of people in the Australian Scleroderma (SSc) Cohort Study with pulmonary arterial hypertension (PAH) with or without interstitial lung disease (ILD). Participants meeting ACR/EULAR criteria for SSc were divided into four mutually exclusive groups: those meeting criteria for PAH (PAH-only), ILD (ILD-only), concurrent PAH and ILD (PAH-ILD) or neither PAH nor ILD (SSc-only).
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Jun 12, 2024 | 
nature.com | Laura Ross
The early decades of the twentieth century were a crucial period for genetics. By 1900, Mendel’s findings had been rediscovered but the physical nature of hereditary remained unclear until 1902–1904, when Sutton and Boveri independently proposed that chromosomes were the bearers of heredity based on their observations of chromosome behaviour during meiosis. This pioneering work laid the foundation of modern genetics.
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May 21, 2024 | 
digitalcommons.library.tmc.edu | Laura Ross |Dylan Hansen |Nancy Maltez |Kathleen Morrisroe
AbstractDigital ulcers (DU) are a common, severe vascular manifestation of systemic sclerosis (SSc) with few effective treatment options.
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Apr 11, 2024 | 
healio.com | Justin Cooper |Shenaz Bagha |Laura Ross
You've successfully added to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Key takeaways: Severe, overlapping symptoms emphasize the complex needs of patients with systemic sclerosis.
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Mar 28, 2024 | 
academic.oup.com | Laura Ross
To quantify the frequency and impact of malnutrition in systemic sclerosis (SSc), as diagnosed by the Global Leadership Initiative on Malnutrition (GLIM) criteria, based on weight loss, body mass index (BMI) and muscle atrophy. Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria for SSc with ≥1 concurrent weight and height measurement were included. Chi-squared tests, two-sample t-tests or Wilcoxon rank-sum tests were used for between-group comparison as appropriate.
