Li Ren

Dec 30, 2024 | nature.com | Tian Li |Shan Jiang |Yuanhao Dai |Xia Wu |Huihui Guo |Li Ren | +7 more

Marine cyclopianes are a family of diterpenoid with novel carbon skeleton and diverse biological activities. Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. Our asymmetric synthesis commences from Wieland-Miescher ketone and features a sequential intramolecular Pauson-Khand reaction and gold-catalyzed Nazarov cyclization to rapidly construct the 6-5-5-5 tetracyclic skeleton. The stereocontrolled cyclopentenone construction is further investigated on complex settings to demonstrate its synthetic utility. Furthermore, using an alkyne-tagged conidiogenone C-derived probe, IRGM1, a master regulator of type I interferon responses, is identified as a key cellular target of conidiogenone C responsible for its anti-inflammatory activity. Preliminary mechanism of action studies shows that conidiogenone C activates IRGM1-mediate dysfunctional mitochondria autophagy to maintain mitochondria quality control of inflammatory macrophages. The cyclopiane diterpenoids are a class of complex natural products with unique carbon skeleton and diverse biological activities. Herein, the authors report the total synthesis and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 as a cellular target of conidiogenone C.

Dec 8, 2024 | onlinelibrary.wiley.com | Yinghui Li |Li Ren |Yingying Yao |Yingyan Zhao

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202417915-sup-0001-SuppMat.docx27.1 MB Supporting Information References 1a) , , Nature 2001, 414, 353; b) , , , , , , , , Nat. Chem. 2022, 14, 1214; c) , , , , , , Energy. Environ. Sci. 2021, 14, 815. 2a) , , , Adv. Mater. 2019, 31, 1902757; b) , , , , , , , , , Nano-Micro Lett. 2023, 15, 93. 3a) , , , , , , , , , , , , Chem. Rev.

Jul 30, 2024 | dx.doi.org | Li Ren |David E. Moreno |Brian Baer |Patrick Barbour

May 28, 2024 | nature.com | Li Ren

AbstractType 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N6-methyladenosine (m6A) of IGF1R remains unclear. Here, we reveal a role for a lncRNA Downregulated RNA in Cancer (DRAIC) suppress tumor growth and metastasis in clear cell Renal Carcinoma (ccRCC).

Feb 26, 2024 | dialnet.unirioja.es | Jun Wang |Li Ren |Hao Zhang

Jun Wang[1];Li Ren[1];Hao Zhang[1][1]El primer hospital de la Universidad de Tsinghua, Beijing, ChinaLocalización: Revista Internacional de Medicina y Ciencias de la Actividad Física y del Deporte, ISSN-e 1577-0354, Nº. 23, 90, 2023, págs.