Shan Jiang

Jan 16, 2025 | onlinelibrary.wiley.com | Shan Jiang |Yingchun Zhang |Wei Zhang

A Physics-guided Neural Network (PgNN) is proposed to provide a robust probability distribution of fatigue life under arbitrary multiple overloads, which integrates the physical mechanism model (PMM) and neural network (NN). Notably, the proposed PgNNs are trained solely using data under constant amplitude loading scenarios. Firstly, a PMM is developed to predict fatigue life based on linear elastic fracture mechanics, considering crack closure.

Jan 5, 2025 | mdpi.com | Shan Jiang

2. Related Work 2.1. Stance Detection MethodStance detection based on machine learning is an important research area within natural language processing, aiming to identify and classify the stance of individuals or groups on specific topics or entities. In recent years, with the development of machine learning techniques, particularly the application of deep learning, significant progress has been made in stance detection research [5,6].

Dec 30, 2024 | nature.com | Tian Li |Shan Jiang |Yuanhao Dai |Xia Wu |Huihui Guo |Li Ren | +7 more

Marine cyclopianes are a family of diterpenoid with novel carbon skeleton and diverse biological activities. Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. Our asymmetric synthesis commences from Wieland-Miescher ketone and features a sequential intramolecular Pauson-Khand reaction and gold-catalyzed Nazarov cyclization to rapidly construct the 6-5-5-5 tetracyclic skeleton. The stereocontrolled cyclopentenone construction is further investigated on complex settings to demonstrate its synthetic utility. Furthermore, using an alkyne-tagged conidiogenone C-derived probe, IRGM1, a master regulator of type I interferon responses, is identified as a key cellular target of conidiogenone C responsible for its anti-inflammatory activity. Preliminary mechanism of action studies shows that conidiogenone C activates IRGM1-mediate dysfunctional mitochondria autophagy to maintain mitochondria quality control of inflammatory macrophages. The cyclopiane diterpenoids are a class of complex natural products with unique carbon skeleton and diverse biological activities. Herein, the authors report the total synthesis and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 as a cellular target of conidiogenone C.

Dec 24, 2024 | mdpi.com | Shan Jiang

Open AccessArticle by Haitao Zhao 1, Dongsheng Wu 2,3,*, Kaiyu Wang 1 and Shan Jiang 2,3 1 Exploration and Development Research Institute of Tarim Oilfield Company, PetroChina, Korla 841000, China 2 Hubei Key Laboratory of Complex Shale Oil and Gas Geology and Development in South China, Yangtze University, Wuhan 430100, China 3 Hubei Engineering Research Center of Unconventional Petroleum Geology and Engineering, Yangtze University, Wuhan 430100, China * Author to whom correspondence should...

Nov 11, 2024 | elifesciences.org | Shan Jiang |Lu Chen |Wei-Min Qu |Zhi-Li Huang

eLife assessment This study presents useful findings for how sevoflurane anesthesia modulates the activity of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus and how manipulation of such PVHCRH neurons influences anesthesia and post-anesthesia responses. The technical approaches are solid and the data presented is largely clear. Whether PVHCRH neurons are critical for the mechanisms of sevoflurane anesthesia is a direction for the future.