Tian Li

2 weeks ago | today.line.me | Wen Tsui |Zhou Saang |Tian Li

A U.S. federal judge has issued an injunction blocking the Trump administration from revoking the legal status of foreign students studying and working in the country. #XinhuaNews

Jan 30, 2025 | today.line.me | Xiong Maoling |Hu Yousong |Liu Yutian |Tian Li

The Chinese Embassy in the United States said on Thursday that two Chinese citizens were among the victims in the mid-air collision of a passenger plane and a helicopter near Reagan National Airport Wednesday night. #XinhuaNews

Jan 29, 2025 | today.line.me | Wang Chenxi |Zhou Saang |Tian Li

The newly installed capacity of renewable energy in 2024 accounted for 86 percent of China's total newly installed power capacity, while the cumulative installed capacity of renewable energy made up a record high of 56 percent of the nation's total, according to new data from the National Energy Administration (NEA). #XinhuaNews

Jan 14, 2025 | today.line.me | Cao Pengyuan |Zhou Saang |Tian Li

The Chinese government has released a list of measures to foster new growth points in the culture and tourism sector and boost related consumption. #XinhuaNews

Dec 30, 2024 | nature.com | Tian Li |Shan Jiang |Yuanhao Dai |Xia Wu |Huihui Guo |Li Ren | +7 more

Marine cyclopianes are a family of diterpenoid with novel carbon skeleton and diverse biological activities. Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. Our asymmetric synthesis commences from Wieland-Miescher ketone and features a sequential intramolecular Pauson-Khand reaction and gold-catalyzed Nazarov cyclization to rapidly construct the 6-5-5-5 tetracyclic skeleton. The stereocontrolled cyclopentenone construction is further investigated on complex settings to demonstrate its synthetic utility. Furthermore, using an alkyne-tagged conidiogenone C-derived probe, IRGM1, a master regulator of type I interferon responses, is identified as a key cellular target of conidiogenone C responsible for its anti-inflammatory activity. Preliminary mechanism of action studies shows that conidiogenone C activates IRGM1-mediate dysfunctional mitochondria autophagy to maintain mitochondria quality control of inflammatory macrophages. The cyclopiane diterpenoids are a class of complex natural products with unique carbon skeleton and diverse biological activities. Herein, the authors report the total synthesis and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 as a cellular target of conidiogenone C.