Lihua Lou

Nov 8, 2024 | nature.com | Jourdan Ewoldt |Samuel J DePalma |Maggie E. Jewett |Lihua Lou |Micheal A. McLellan |Jin He | +7 more

AbstractRecent innovations in differentiating cardiomyocytes from human induced pluripotent stem cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently, hiPSC-derived cardiomyocytes (hiPSC-CMs) remain immature, leading many in the field to explore approaches to enhance cell and tissue maturation.

Apr 20, 2024 | dx.doi.org | Lihua Lou |Alberto Sesena Rubfiaro |Victor Deng |Jin He

Engineered cardiac tissues show potential for regenerative therapy in ischemic heart disease. Yet, selection of soft biomaterials for scaffold manufacturing is primarily influenced by empirical and compositional factors, raising concerns about arrhythmic risks due to poor electrophysiological integration. Addressing this, we developed multiscale hybrid myocardial patches mimicking native myocardium’s structural and biomechanical attributes, utilizing 3D printing and electrospinning techniques.