Lin Dong

Dec 17, 2024 | pubs.rsc.org | Lin Dong

Advancements in flexible biomechanical energy harvesting for smart health applications Advancing flexible electronics enables timely, smart health management and diagnostic interventions. However, current health electronics typically rely on replaceable batteries or external power sources, requiring direct contact with the human skin or organs. This setup often results in rigid and bulky devices, reducing user comfort during long-term use.

Oct 23, 2024 | scijournals.onlinelibrary.wiley.com | Lin Zhang |Lin Dong |Hua Zhang |Xia Ma

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Oct 16, 2024 | nature.com | Lin Dong |Weizhen Li |Min Zhang |Lijuan Yan |Qiong Yu |Yanchi Zhang | +2 more

Observational studies have shown some association between cannabis use disorder (CUD) and neurological disorders, but their causal relationship is unclear. In this study, we tested the potential causal relationship between CUD and three common neurological disorders using two-sample Mendelian randomization (TSMR) and multivariate MR (MVMR) methods. Thirty-two genetic loci were extracted as exposure factors from the largest genome-wide association study (GWAS) summary statistics for CUD to date. TSMR results showed that genetic prediction of CUD with all stroke, ischemic stroke, large-artery atherosclerotic stroke, migraine with aura, and Alzheimer’s disease (AD) had a positive causal relationship (P < 0.05), which was not found in several other diseases. The association between CUD and stroke, ischemic stroke, and AD in the MVMR study may have been influenced by confounding factors (P > 0.05). Subgroup analyses highlighted a causal relationship between genetically predicted CUD and large-artery atherosclerotic stroke (OR = 1.169; 95%CI 1.030–1.328; P = 0.016) and migraine with aura (OR = 1.142; 95% 1.021–1.278; P = 0.020). Our further functional mapping and annotation enrichment analyses using FUMA suggest that the brain-gut axis may serve as another layer of explanation for the existence of an association between CUD and neurological disorders.

Oct 10, 2024 | mdpi.com | Yun Zhu |Ying Li |Dong Li |Lin Dong

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Oct 8, 2024 | pubs.rsc.org | Lin Dong |Chao Zhang

L. Dong and C. Zhang, Org. Biomol. Chem., 2024, Accepted Manuscript , DOI: 10.1039/D4OB01631A To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.