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1 week ago | 
nature.com | Yan Liu |Anchao Yang |Fangang Meng |Huaying Fang |Ruquan Han |Jianguo Zhang | +3 more
Deep Brain Stimulation (DBS) is a critical intervention for various neurological disorders. While effective, the traditional local infiltration anesthesia used in DBS surgeries often hinders electrophysiological recording quality and patient cooperativeness. The research aims to evaluate the impact of local infiltration versus scalp block anesthetic methods on electrophysiological signal quality and patient cooperativeness during DBS surgeries. This study involved patients who participated in an intraoperative task during the bilateral subthalamic nucleus DBS surgery for Parkinson’s Disease between Jan 2020 and Dec 2022. Patients were either administered the traditional local infiltration anesthesia or the modified scalp block anesthesia. Intraoperative electrophysiological recording data and anesthetic data was collected. Spike sorting was performed to evaluate the recording stability. Patient cooperativeness and intraoperative experience was assessed and compared. The patients under scalp block anesthesia exhibited shorter pre-acquisition time, longer stable recording time, higher number of tasks per site, higher number of neurons recorded per task (all ps < 0.05). In behavior, patients under scalp block anesthesia showed higher accuracy in tasks (p < 0.05), while the response time was comparable. The overall satisfaction of anesthesia was also higher in scalp block, as revealed by the visual analogue scale, Likert scale and mean arterial pressure (all ps < 0.05). The modified scalp block anesthetic method offers considerable advantages over traditional local infiltration anesthesia in DBS surgeries. It helps to improve both patient comfort and cooperation during the surgery, and thereby enhancing the overall quality of neurological data and efficacy of DBS procedures.
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Jan 22, 2025 | 
dx.doi.org | Xin Wang |Wei Jia |Rong Zhang |Lin Shi
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Jan 22, 2025 | 
pubs.acs.org | Xin Wang |Wei Jia |Rong Zhang |Lin Shi
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Nov 10, 2024 | 
flipboard.com | Lin Shi
Fact Check: Did Republicans Just Introduce Bill to Reduce Social Security? Republicans and Democrats have fiercely debated how best to handle the impending Social Security funding crisis. While Americans have been paying into …
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Nov 10, 2024 | 
theprint.in | Lin Shi |David Knox
Lifespans and the cost of living are rising beyond what retirement income systems were built to support. Demographic ageing, along with decades of declining birth rates, is profoundly impacting the economic and social foundations of many countries. Living longer is a remarkable achievement, but how do we fund these extra years? Covering basic expenses could require people to work longer, save and invest more aggressively or adjust their standards of living.
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Nov 7, 2024 | 
weforum.org | Lin Shi
AI has potential uses in addressing the challenges of an ageing population and ensuring a positive retirement. Image: Getty Images/iStockphotoSenior Partner and National Leader of the Research Practice in Australia, Mercer (MMC)Project Fellow, Longevity Economy, Marsh McLennanThe world is going through a seismic demographic transition, as populations age and traditional workforces shrink, prompting challenges for retirement systems that need to adapt to remain resilient.
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Nov 7, 2024 | 
flipboard.com | David Knox |Lin Shi
NowZero-knowledge (ZK) technology has become some of the hottest property in the blockchain sphere over the last few years, powering an entire ecosystem of Layer 2s that bring scalability, lower fees, and many other features and enhancements to the Ethereum landscape. However, so far, the application …
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Sep 11, 2024 | 
mdpi.com | Lin Shi |Weitao Liu |Yafeng Wu |Chenxu Dai
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 16, 2024 | 
mdpi.com | Ying Ma |Lin Shi |Liang Chen |Cai Chen
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Mar 26, 2024 | 
nature.com | LinLin Zhang |Yuanyuan Chen |Lin Shi |Yongzhao Fan
This study aimed to investigate structural synaptic plasticity in the medial prefrontal cortex of rats under treadmill exercise pretreatment or naive conditions in a vascular dementia model, followed by recognition memory performance in a novel object recognition task. In this study, 24 Sprague–Dawley rats were obtained and randomly assigned into 4 groups as follows: control group (Con group, n = 6), vascular dementia (VD group, n = 6), exercise and vascular dementia group (Exe + VD group, n = 6), and exercise group (Exe group, n = 6). Initially, 4 weeks of treadmill exercise intervention was administered to the rats in the Exe + VD and Exe groups. Then, to establish the vascular dementia model, the rats both in the VD and Exe + VD groups were subjected to bilateral common carotids arteries surgery. One week later, open-field task and novel recognition memory task were adopted to evaluate anxiety-like behavior and recognition memory in each group. Then, immunofluorescence and Golgi staining were used to evaluate neuronal number and spine density in the rat medial prefrontal cortex. Transmission electron microscopy was used to observe the synaptic ultrastructure. Finally, microdialysis coupled with high-performance liquid chromatography was used to assess the levels of 5-HT and dopamine in the medial prefrontal cortex. The behavior results showed that 4 weeks of treadmill exercise pretreatment significantly alleviated recognition memory impairment and anxiety-like behavior in VD rats (P < 0.01), while the rats in VD group exhibited impaired recognition memory and anxiety-like behavior when compared with the Con group (P < 0.001). Additionally, NeuN immunostaining results revealed a significant decrease of NeuN-marked neuron in the VD group compared to Con group (P < 0.01), but a significantly increase in this molecular marker was found in the Exe + VD group compared to the Con group (P < 0.01). Golgi staining results showed that the medial prefrontal cortex neurons in the VD group displayed fewer dendritic spines than those in the Con group (P < 0.01), and there were more spines on the dendrites of medial prefrontal cortex cells in Exe + VD rats than in VD rats (P < 0.01). Transmission electron microscopy further revealed that there was a significant reduction of synapses intensity in the medial prefrontal cortex of rats in the VD group when compared with the Con group(P < 0.01), but physical exercise was found to significantly increased synapses intensity in the VD model (P < 0.01). Lastly, the levels of dopamine and 5-HT in the medial prefrontal cortex of rats in the VD group was significantly lower compared to the Con group (P < 0.01), and treadmill exercise was shown to significantly increased the levels of dopamine and 5-HT in the VD rats (P < 0.05). Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in VD rat and improved recognition memory.
