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Oct 10, 2024 | 00358-1&sz=64)
cell.com | Precision Immuno-Oncology |Lorenzo Galluzzi
1Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA 2Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA 3Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH, USA 4National Center for Regenerative Medicine, Cleveland, OH, USA 5Case Comprehensive Cancer Center, Cleveland, OH, USA 6Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy 7Candiolo Cancer Institute, FPO -...
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Jun 3, 2024 | 
nature.com | Lorenzo Galluzzi
TCDD-inducible poly(ADP-ribose) polymerase (TIPARP, best known as PARP7) has previously been shown to promote oncogenesis by limiting the cytosolic accumulation of potentially interferogenic nucleic acids in malignant cells or the precursors thereof. Recent data indicate that the oncogenic activity of PARP7 is derived at least partially from its ability to suppress apoptotic cell death upon mono-ADP-ribosylation of FOS-like 1, AP-1 transcription factor subunit (FOSL1, best known as FRA1) [1].
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Apr 20, 2024 | 
nature.com | Kristopher A. Sarosiek |Lorenzo Galluzzi
Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.
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Apr 8, 2024 | 
nature.com | Lorenzo Galluzzi
AbstractThe etiology of various neurodegenerative disorders that mainly affect the central nervous system including (but not limited to) Alzheimer’s disease, Parkinson’s disease and Huntington’s disease has classically been attributed to neuronal defects that culminate with the loss of specific neuronal populations.
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Feb 29, 2024 | 
nature.com | Enyong Dai |Xin McRae Chen |Xuejun Jiang |Rui Kang |Valerian E. Kagan |Ana J. García-Sáez | +27 more
AbstractFerroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity.
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Oct 25, 2023 | 
acsjournals.onlinelibrary.wiley.com | Guido Kroemer |Timothy Chan |Lorenzo Galluzzi
INTRODUCTION Until the beginning of the 21st century, cancer was largely viewed as a purely cell-intrinsic disease of genetic or epigenetic origin, implying that personalized treatment strategies were mostly focused on dissecting malignant cell features.1 However, cancer is a systemic disease that involves a progressive derailment of immunological, metabolic, neuroendocrine, and potentially microbial features, hence affecting the entire bodywide ecosystem.2, 3 This notion has been...
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Aug 21, 2023 | 
nature.com | Lorenzo Galluzzi
The secretion of interferon gamma (IFNG, best known as IFNγ) by immune effector cells generally mediates potent anticancer effects. Recent data from Beziaud et al. demonstrate that—at least in some circumstances—IFNγ can edit the breast cancer microenvironment to promote stemness, disease progression and resistance to (immuno)therapy.
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Jun 6, 2023 | 
nature.com | Lorenzo Galluzzi
AbstractImmunotherapy has revolutionized the clinical management of many malignancies but is infrequently associated with durable objective responses when used as a standalone treatment approach, calling for the development of combinatorial regimens with superior efficacy and acceptable toxicity.
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May 4, 2023 | 
nature.com | Lorenzo Galluzzi
AbstractAutologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 are approved for the treatment of various CD19+ hematological malignancies. While CAR T cells induce objective responses in a majority of patients, relapse frequently occurs upon loss of CD19 expression by neoplastic cells. Radiation therapy (RT) has been successfully employed to circumvent the loss of CAR targets in preclinical models of pancreatic cancer.
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Mar 16, 2023 | 00045-5&sz=64)
cell.com | Claire Vanpouille-Box |Lorenzo Galluzzi
Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al . suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading exonucleases to proteasomal processing.
