Luca Mazzarella

Dec 19, 2023 | science.org | Luca Mazzarella |Antje Schaefer |Yuanyuan Li |Annalisa M. VanHook

Editors' ChoiceHOST-PATHOGEN INTERACTIONSAnnalisa M. VanHook https://orcid.org/0000-0002-5989-6767Authors Info & AffiliationsScience Signaling19 Dec 2023Vol 16, Issue 816AbstractA Mycobacterium tuberculosis virulence factor promotes foam cell formation by inhibiting DNA repair. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily M.

Dec 19, 2023 | science.org | Luca Mazzarella |Antje Schaefer |Yuanyuan Li |Richa Shah |Samanta Sarti |Alicia L Belcher | +11 more

Research ArticleDNA DAMAGEYuanyuan Li https://orcid.org/0000-0002-1124-9421, Richa B. Shah https://orcid.org/0000-0003-2805-6770, [...] , Samanta Sarti, Alicia L. Belcher, [...] , Brian J. Lee https://orcid.org/0000-0001-5550-1468, Andrej Gorbatenko https://orcid.org/0000-0002-0077-1679, Francesca Nemati, Honglin Yu, Zoe Stanley https://orcid.org/0009-0000-1792-5315, [...] , Mahbuba Rahman, Zhengping Shao, Jose M.

Dec 19, 2023 | sciencemag.org | Luca Mazzarella |Antje Schaefer |Yuanyuan Li |Richa Shah

MATERIALS AND METHODSHeLa (cervical, p53-degraded via HPV-E6), CAL27 [head and neck squamous cell carcinoma (HNSCC), TP53 H183L], SAS (HNSCC, TP53 E336*), MCF7, and MDA-MB-231 (breast, TP53 R280K) cell lines were cultured in Dulbecco’s modified Eagle’s medium (DMEM) (Life Technologies) supplemented with 10% fetal bovine serum (FBS) (Sigma-Aldrich) and 1% penicillin-streptomycin (P/S) (Life Technologies).

Dec 12, 2023 | sciencemag.org | Luca Mazzarella |Antje Schaefer |Yuanyuan Li |Zbigniew Korwek

Information & AuthorsPublished In Science SignalingVolume 16 | Issue 815December 2023Article versionsSubmission historyReceived: 18 March 2022Accepted: 22 November 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank B. Moss for sharing the PKR KO, RNase L KO, and PKR and RNase L dKO A549 cell lines. We thank B. Tarkowski for generating a CRISPR plasmid construct targeting MAVS, and F. Grabowski, P. Nałęcz-Jawecki, P. Koza, and K. Tudelska for discussion.