Luis Ferrández-Peral

May 23, 2024 | nature.com | Luis Ferrández-Peral |Claudia Fontsere |Merve Ceylan |Giovanni Lara |Jacques Dainat |Arthur O. Zalevsky | +8 more

AbstractSLC22A10 is an orphan transporter with unknown substrates and function. The goal of this study is to elucidate its substrate specificity and functional characteristics. In contrast to orthologs from great apes, human SLC22A10, tagged with green fluorescent protein, is not expressed on the plasma membrane. Cells expressing great ape SLC22A10 orthologs exhibit significant accumulation of estradiol-17β-glucuronide, unlike those expressing human SLC22A10.

Aug 12, 2023 | biorxiv.org | Luis Ferrández-Peral |Claudia Fontsere |Merve Ceylan |Pol Alentorn

AbstractSLC22A10 is classified as an orphan transporter with unknown substrates and function. Here we describe the discovery of the substrate specificity and functional characteristics of SLC22A10. The human SLC22A10 tagged with green fluorescent protein was found to be absent from the plasma membrane, in contrast to the SLC22A10 orthologs found in great apes. Estradiol-17β-glucuronide accumulated in cells expressing great ape SLC22A10 orthologs (over 4-fold, p<0.001).