Pol Alentorn

Aug 12, 2023 | biorxiv.org | Luis Ferrández-Peral |Claudia Fontsere |Merve Ceylan |Pol Alentorn

AbstractSLC22A10 is classified as an orphan transporter with unknown substrates and function. Here we describe the discovery of the substrate specificity and functional characteristics of SLC22A10. The human SLC22A10 tagged with green fluorescent protein was found to be absent from the plasma membrane, in contrast to the SLC22A10 orthologs found in great apes. Estradiol-17β-glucuronide accumulated in cells expressing great ape SLC22A10 orthologs (over 4-fold, p<0.001).