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2 months ago | 
digitalcommons.library.tmc.edu | Nuria Hermosilla-Albala |Felipe Ennes Silva |Sebastian Cuadros-Espinoza |Claudia Fontsere
KeywordsAnimals, Genome, Genetic Variation, Rainforest, Phylogeny, Ecosystem, Brazil, Gene Flow, Platyrrhini, Evolutionary biology, Evolutionary genetics, Ecological genetics, BiogeographyAbstractDespite showing the greatest primate diversity on the planet, genomic studies on Amazonian primates show very little representation in the literature.
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Jan 9, 2025 | 
science.org | Harrison J. Ostridge |Arindam Ghosh |Anqi Wei |Claudia Fontsere
Editor’s summaryAdaptation to different environments can include responding to a myriad of pressures, from diseases to differences in water abundance. Of the great apes, chimpanzees are most similar to humans in that they inhabit a range of environments from savannahs to rainforests. Ostridge et al. sequenced exomes from 388 chimpanzees using fecal samples to investigate how selection has acted on these animals.
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Oct 7, 2024 | 
nature.com | Nuria Hermosilla-Albala |Claudia Fontsere |Joanna L. Kelley |Pol Alentorn-Moron |Esther Lizano |Izeni Farias | +4 more
AbstractDespite showing the greatest primate diversity on the planet, genomic studies on Amazonian primates show very little representation in the literature. With 48 geolocalized high coverage whole genomes from wild uakari monkeys, we present the first population-level study on platyrrhines using whole genome data.
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Oct 4, 2024 | 
elifesciences.org | Claudia Fontsere |Pere Renom |Josefin Stiller |Laia Llovera
eLife assessment This important study illustrates the value of museum samples for understanding past genetic variability in the genomes of populations and species, including those that no longer exist.
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May 23, 2024 | 
nature.com | Luis Ferrández-Peral |Claudia Fontsere |Merve Ceylan |Giovanni Lara |Jacques Dainat |Arthur O. Zalevsky | +8 more
AbstractSLC22A10 is an orphan transporter with unknown substrates and function. The goal of this study is to elucidate its substrate specificity and functional characteristics. In contrast to orthologs from great apes, human SLC22A10, tagged with green fluorescent protein, is not expressed on the plasma membrane. Cells expressing great ape SLC22A10 orthologs exhibit significant accumulation of estradiol-17β-glucuronide, unlike those expressing human SLC22A10.
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Apr 24, 2024 | 
biorxiv.org | Nuria Hermosilla-Albala |Felipe Ennes Silva |Sebastian Cuadros-Espinoza |Claudia Fontsere
AbstractDespite showing the greatest primate diversity on the planet, genomic studies on Amazonian primates show very little representation in the literature. With 48 geolocalized high coverage whole genomes from wild uakari monkeys, we present the first population-level study on platyrrhines using whole genome data.
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Sep 13, 2023 | 
onlinelibrary.wiley.com | Linett Rasmussen |Claudia Fontsere |Universidad de Antioquia |Iván D. Soto-Calderón
1 INTRODUCTION Cotton-top tamarins are a primate species endemic to Colombia (Mast et al., 1993). These tamarins have a dispirited backstory related to their former use in biomedical research facilities. Specifically, in the 1960s, it was discovered that their physiology rendered them a suitable model for studying a variety of human diseases, from Epstein–Barr virus to colitis and colon cancer (Mast et al., 1993).
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Aug 15, 2023 | 
biorxiv.org | Martin Kuhlwilm |Federico Battiston |Claudia Fontsere |Cassandra Gunasekaram
AbstractWhile cumulative culture is a hallmark of hominin evolution, its origins can be traced back to our common ancestor with chimpanzees. Here we investigate the evolutionary origins of chimpanzee cumulative culture, and why it remained incipient. To trace cultural transmission among the four chimpanzee subspecies, we built between-populations networks based on genetic markers of recent migration and shared cultural traits.
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Aug 12, 2023 | 
biorxiv.org | Luis Ferrández-Peral |Claudia Fontsere |Merve Ceylan |Pol Alentorn
AbstractSLC22A10 is classified as an orphan transporter with unknown substrates and function. Here we describe the discovery of the substrate specificity and functional characteristics of SLC22A10. The human SLC22A10 tagged with green fluorescent protein was found to be absent from the plasma membrane, in contrast to the SLC22A10 orthologs found in great apes. Estradiol-17β-glucuronide accumulated in cells expressing great ape SLC22A10 orthologs (over 4-fold, p<0.001).
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Jul 25, 2023 | 
biorxiv.org | Felipe Ennes Silva |Sebastian Cuadros-Espinoza |Claudia Fontsere |Nuria Hermosilla-Albala
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