Lydia Lynch

Nov 14, 2024 | nature.com | Ilya Korsunsky |William V Trim |Anna Jonsson |fan zhang |Kevin H-C Wei |Lydia Lynch

AbstractFibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing and identify a gene expression program in healthy synovial fibroblasts characterized by enhanced fatty acid metabolism and lipid transport.

Mar 27, 2024 | nature.com | Lydia Lynch

Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1+ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1+ Vδ1+ T cells are repressed after engagement of PD-1 by PD-L1.

Jul 20, 2023 | nature.com | Aaron Douglas |Lydia Lynch

Authors and AffiliationsSchool of Biochemistry and Immunology, TBSI, Trinity College Dublin, Dublin, IrelandAaron Douglas, Brenneth Stevens & Lydia LynchBrigham and Women’s Hospital, Harvard Medical School, Boston, MA, USABrenneth Stevens & Lydia LynchContributionsA.D. and B.S. drafted the figures, and L.L. revised the final version of the figures. A.D., B.S. and L.L. jointly conceived, wrote and revised the final version of the manuscript. Corresponding author

Feb 6, 2023 | cell.com | Hui-Fern Koay |Lydia Lynch

Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al . reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.