Ilya Korsunsky

Nov 27, 2024 | cell.com | Lucy Macdonald |Aziza Elmesmari |Domenico Somma |Jack Frew |Clara Di Mario |Roopa Madhu | +30 more

Keywordsimmune tolerancearthritisdisease remissiondendritic cellssynovial tissuespatial transcriptomicsT cellsIntroductionRheumatoid arthritis (RA) is an inflammatory joint disease with systemic comorbidities, driven by the breach of immune tolerance.1 Advances in targeted therapies2 have transformed the management of RA.

Nov 14, 2024 | nature.com | Ilya Korsunsky |William V Trim |Anna Jonsson |fan zhang |Kevin H-C Wei |Lydia Lynch

AbstractFibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing and identify a gene expression program in healthy synovial fibroblasts characterized by enhanced fatty acid metabolism and lipid transport.