Madeeha Afzal

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Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses - Nature Nanotechnology

May 6, 2024 | nature.com | Rory A Hills |Tiong Kit Tan |Alexander Cohen |Jennifer R. Keeffe |Michelle Hill |Madeeha Afzal | +7 more

AbstractDefending against future pandemics requires vaccine platforms that protect across a range of related pathogens. Nanoscale patterning can be used to address this issue. Here, we produce quartets of linked receptor-binding domains (RBDs) from a panel of SARS-like betacoronaviruses, coupled to a computationally designed nanocage through SpyTag/SpyCatcher links.

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