Marco Prinz

Oct 7, 2024 | nature.com | Adrià Dalmau Gasull |Marco Prinz

In their paper published in Cell,1 Xu et al. leveraged single-cell sequencing and cell lineage tracing tools combined with two-photon live imaging to characterise the spatiotemporal immune recruitment and infiltration to the choroid plexus (ChP). They provide seminal insights into the communication between specialised ChP epithelial and macrophage populations, which coordinate the stepwise response to inflammation and its resolution.

Aug 13, 2024 | nature.com | Patrick Metzger |Jesús Duque-Afonso |Tilman Brummer |Marco Prinz |Roman Sankowski |Melanie Börries

AbstractDespite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we explored the feasibility of individual molecular profiling and the efficacy of biomarker-guided therapy for adult patients with primary brain cancers in the real-world setting within the molecular tumor board Freiburg, Germany.

Nov 27, 2023 | nature.com | Marco Prinz

Macrophages (MΦs) are versatile cells found in every organ. Throughout the body, they work tirelessly to maintain tissues. To this end, they are instructed by their respective niches to express organ-specific genes and proteins, resulting in a variety of cell morphologies and highly specialized functions across different tissues [1]. A recent study by Wang et al.

Nov 12, 2023 | nature.com | Julio Aguado |Atefeh Taherian Fard |Eduardo A. Albornoz |Alexander Tyshkovskiy |Marius Schwabenland |Benjamin Liang | +8 more

AbstractAging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on neuropathologies is unknown. Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate transcriptomic aging clocks.

Oct 23, 2023 | nature.com | Marco Prinz

Two new studies in which apoE expression in mice is manipulated provide insights into the roles of microglial apoE in neurodegeneration. Benjamin Franklin’s advice “An ounce of prevention is worth a pound of cure” holds a grain of wisdom for the medical community. There is currently no preventive treatment or cure for late-onset Alzheimer’s disease — the most common form of dementia — and the disease is developing into a global health issue1.