Maria Kalogeraki

Oct 29, 2024 | science.org | Vincent Rondeau |Zhigang Li |Amy Baek |Maria Kalogeraki

Editor’s summaryTruncations of the chemokine receptor CXCR4 prevent its internalization and cause WHIM syndrome, an inherited immunodeficiency characterized by increased numbers of myeloid cells in the bone marrow. In a mouse model of WHIM syndrome, Rondeau et al. found that a subset of multipotent progenitor cells that normally adopt a lymphoid fate were reprogrammed to instead adopt a myeloid fate.